1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

Names

[ CAS No. ]:
57653-85-7

[ Name ]:
1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

[Synonym ]:
1,2,3,6,7,8-hexachlorodibenzo-p-dioxin

Chemical & Physical Properties

[ Density]:
1.777 g/cm3

[ Boiling Point ]:
478ºC at 760 mmHg

[ Melting Point ]:
285-286ºC

[ Molecular Formula ]:
C₁₂H₂Cl₆O₂

[ Molecular Weight ]:
390.86100

[ Flash Point ]:
182.9ºC

[ Exact Mass ]:
387.81900

[ PSA ]:
18.46000

[ LogP ]:
7.50500

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP3280100

CHEMICAL NAME :: Dibenzo-p-dioxin, 1,2,3,6,7,8-hexachloro-

CAS REGISTRY NUMBER :: 57653-85-7

BEILSTEIN REFERENCE NO. :: 1627652

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H2-Cl6-O2

MOLECULAR WEIGHT :: 390.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 70 ug/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 ug/kg/14D-C

TOXIC EFFECTS :: Immunological Including Allergic - decrease in humoral immune response

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - mouse Fibroblast

DOSE/DURATION :: 400 pmol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1485,1987 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,41,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,41,1977 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 69,33,1997

Safety Information

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1(a)