9-(2,2-Dicyanovinyl)julolidine

Names

[ Name ]:
9-(2,2-Dicyanovinyl)julolidine

[Synonym ]:
dcvj

Biological Activity

[Description]:

DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Furuno T, et al. A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol Lett. 1992;33(3):285-288.

[2]. Furuno T, et al. A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol Lett. 1992;33(3):285-288.

Chemical & Physical Properties

[ Density]:
1.23 g/cm3

[ Boiling Point ]:
470.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₅N₃

[ Molecular Weight ]:
249.31000

[ Flash Point ]:
214.6ºC

[ Exact Mass ]:
249.12700

[ PSA ]:
50.82000

[ LogP ]:
2.88096

[ Index of Refraction ]:
1.634

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO4445000

CHEMICAL NAME :: Malononitrile, (2,3,6,7-tetrahydro-1H,5H-benzo(ij)quinolizin-9-ylmet hylene)-

CAS REGISTRY NUMBER :: 58293-56-4

BEILSTEIN REFERENCE NO. :: 0240710

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H15-N3

MOLECULAR WEIGHT :: 249.34

WISWESSER LINE NOTATION :: T666 1A M BNT&TJ H1UYCN&CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#08444

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
OO4445000

Precursor & DownStream

Precursor

DownStream

Articles

Fluorescent molecular rotors: a new class of probes for tubulin structure and assembly.

Biochemistry 28 , 6678, (1989)

9-(Dicyanovinyl)julolidine (DCVJ) is a fluorescent dye whose intramolecular rotational relaxation is solvent dependent. Since its quantum yield increases with decreasing free volume, this molecule has...

9-(Dicyanovinyl)julolidine binding to bovine brain calmodulin.

J. Biochem. 109 , 499, (1991)

A molecular rotor, 9-(dicyanovinyl)julolidine (DCVJ), is a fluorescent dye whose intramolecular rotation determines its fluorescence yield [Kung, C.E. & Reed, J.K. (1989) Biochemistry 28, 6678-6686]. ...

Antibodies for fluorescent molecular rotors.

Biochemistry 32 , 7589, (1993)

We have prepared monoclonal antibodies for the fluorescent molecular rotors 9-(2-carboxy-2-cyanovinyl)julolidine (CCVJ) and 9-(dicyanovinyl)julolidine (DCVJ). Mouse monoclonal antibody (IgG2b) prepare...