2-chloroacetanilide

Names

[ CAS No. ]:
587-65-5

[ Name ]:
2-chloroacetanilide

[Synonym ]:
Chloroacetanilide
N-(2-chloroacetyl)aniline
N-chloroacetylaniline
N-phenyl-2-chloroacetamide
Acetamide,2-chloro-N-phenyl
Acetanilide,2-chloro
2-Chloroacetanilide
MFCD00018887
EINECS 209-604-0
N-Phenylchloroacetamide

Chemical & Physical Properties

[ Density]:
1.266 g/cm3

[ Boiling Point ]:
340ºC at 760 mmHg

[ Melting Point ]:
136-139 °C(lit.)

[ Molecular Formula ]:
C₈H₈ClNO

[ Molecular Weight ]:
169.60800

[ Flash Point ]:
159.5ºC

[ Exact Mass ]:
169.02900

[ PSA ]:
29.10000

[ LogP ]:
1.93690

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE1000000

CHEMICAL NAME :: Acetanilide, 2-chloro-

CAS REGISTRY NUMBER :: 587-65-5

BEILSTEIN REFERENCE NO. :: 0509684

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H8-Cl-N-O

MOLECULAR WEIGHT :: 169.62

WISWESSER LINE NOTATION :: G1VMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 810 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 48,204,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 48,204,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00010

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AE1000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Risk assessment of pesticides detected in surface water of the Alqueva reservoir (Guadiana basin, southern of Portugal).

Sci. Total Environ. 488-489 , 208-19, (2014)

The purpose of this study was to evaluate the potential impact of the pesticides detected in the Alqueva reservoir (Guadiana Basin, South Iberian Peninsula) on the aquatic organisms belonging to this ...

Biotransformation of monochloroanilines in guppy, Poecilia reticulata.

Xenobiotica 24(1) , 59-69, (1994)

1. Guppies (Poecilia reticulata) were exposed for 96 h to 4-chloroaniline (4CA), 3-chloroaniline (3CA) and 2-chloroaniline (2CA) in a static exposure system. 4-Chloroacetanilide (N4CA), 3-chloroacetan...

Determination of sulfonic acid degradates of chloroacetanilide and chloroacetamide herbicides in groundwater by LC/MS/MS.

Anal. Chem. 70(13) , 2699-703, (1998)

An analytical method is presented which permits qualitative and quantitative analysis of sulfonic acid degradates of three chloroacetanilide herbicides (acetochlor, alachlor, and metolachlor) and one ...