4-Amino-1-naphthonitrile

Names

[ Name ]:
4-Amino-1-naphthonitrile

[Synonym ]:
MFCD00004022
1-cyano-4-aminonaphthalene
1-amino-4-cyanonaphthalene
4-cyano-1-aminonaphthalene
4-Amino-1-naphthonitrile
4-amino-1-naphthalene-carbonitrile
4-cyano-1-naphthylamine
1-Naphthalenecarbonitrile, 4-amino-
1-NAPHTHALENECARBONITRILE,4-AMINO
EINECS 261-412-6

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
392.4±25.0 °C at 760 mmHg

[ Melting Point ]:
174.5-176.5ºC(lit.)

[ Molecular Formula ]:
C₁₁H₈N₂

[ Molecular Weight ]:
168.195

[ Flash Point ]:
191.1±23.2 °C

[ Exact Mass ]:
168.068741

[ PSA ]:
49.81000

[ LogP ]:
2.30

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.687

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ1865000

CHEMICAL NAME :: 1-Naphthalenecarbonitrile, 4-amino-

CAS REGISTRY NUMBER :: 58728-64-6

BEILSTEIN REFERENCE NO. :: 2937292

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H8-N2

MOLECULAR WEIGHT :: 168.21

WISWESSER LINE NOTATION :: L66J BZ ECN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05168

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21

[ Safety Phrases ]:
S23

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2926909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors.

Bioorg. Med. Chem. 7(12) , 3011-24, (1999)

Cysteine farnesylation at the carboxylate terminal tetrapeptide CAAX of Ras protein is catalyzed by farnesyltransferase. This lipid modification is necessary for regulatory function of both normal and...