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HlyU inhibitor CM14

Names

[ CAS No. ]:
588678-13-1

[ Name ]:
HlyU inhibitor CM14

[Synonym ]:
MFCD03943922
2-Propynamide, N-(4-oxo-4H-thieno[3,4-c][1]benzopyran-3-yl)-3-phenyl-
N-(4-Oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenyl-2-propynamide

Biological Activity

[Description]:

HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30; reduces HlyU-dependent expression of virulence genes in V. vulnificus. In addition to the decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death; also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.

[References]

References 1. Lee ZW, et al. Sci Rep. 2019 Mar 13;9(1):4346. doi: 10.1038/s41598-019-39554-y. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C20H11NO3S

[ Molecular Weight ]:
345.371

[ Exact Mass ]:
345.045959

[ LogP ]:
6.22

[ Index of Refraction ]:
1.731

Related Compounds