Cyclizine dihydrochloride
Names
[ CAS No. ]:
5897-18-7
[ Name ]:
Cyclizine dihydrochloride
[Synonym ]:
Cyclizine dihydrochloride
Cyclizine 2HCl
Chemical & Physical Properties
[ Molecular Formula ]:
C18H23ClN2
[ Molecular Weight ]:
302.84200
[ Exact Mass ]:
302.15500
[ PSA ]:
6.48000
[ LogP ]:
3.70120
[ Storage condition ]:
-20℃
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TL6490000
- CHEMICAL NAME :
- Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
- CAS REGISTRY NUMBER :
- 5897-18-7
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C18-H22-N2.2Cl-H
- MOLECULAR WEIGHT :
- 339.34
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 69 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,279,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11928 mg/kg/12W-C
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,297,1954