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NEK6 inibitor 8

Names

[ CAS No. ]:
591239-68-8

[ Name ]:
NEK6 inibitor 8

[Synonym ]:
(5Z)-2-Hydroxy-4-methyl-6-oxo-5-[(5-phenyl-2-furyl)methylene]-5,6-dihydropyridine-3-carbonitrile
3-Pyridinecarbonitrile, 1,2,5,6-tetrahydro-4-methyl-2,6-dioxo-5-[(5-phenyl-2-furanyl)methylene]-, (5Z)-
3-pyridinecarbonitrile, 5,6-dihydro-2-hydroxy-4-methyl-6-oxo-5-[(5-phenyl-2-furanyl)methylene]-, (5Z)-
(5Z)-4-Methyl-2,6-dioxo-5-[(5-phenyl-2-furyl)methylene]-1,2,5,6-tetrahydro-3-pyridinecarbonitrile

Biological Activity

[Description]:

NEK6 inibitor 8 (ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9; dispalys antiproliferative activity against a panel of human cancer cell lines (IC50 <100 uM).

[References]

References 1. De Donato M, et al. Sci Rep. 2018 Oct 30;8(1):16047. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
504.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H12N2O3

[ Molecular Weight ]:
304.299

[ Flash Point ]:
259.2±30.1 °C

[ Exact Mass ]:
304.084778

[ LogP ]:
3.44

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.646

Related Compounds