4-Amino-1-naphthol Hydrochloride

Names

[ Name ]:
4-Amino-1-naphthol Hydrochloride

[Synonym ]:
1-Naphthalenol, 4-amino-
4-Amino-1-naphthol
4-aminonaphthalen-1-ol,hydrochloride
1-AMINO-4-NAPHTHOL
4-aminonaphthalen-1-ol
4-Amino-1-naphthalenol
MFCD00012562
EINECS 227-727-8
4-Amino-1-naphthol . HCl

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
386.8±25.0 °C at 760 mmHg

[ Melting Point ]:
273 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₉NO

[ Molecular Weight ]:
159.185

[ Flash Point ]:
187.8±23.2 °C

[ Exact Mass ]:
159.068420

[ PSA ]:
46.25000

[ LogP ]:
0.94

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.742

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL3342000

CHEMICAL NAME :: 1-Naphthol, 4-amino-, hydrochloride

CAS REGISTRY NUMBER :: 5959-56-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H9-N-O.Cl-H

MOLECULAR WEIGHT :: 195.66

WISWESSER LINE NOTATION :: L66J BZ EQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 12,222,1958

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QL3342000

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Rational design of indoleamine 2,3-dioxygenase inhibitors.

J. Med. Chem. 53 , 1172-89, (2010)

Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorit...

Affinity chromatography on immobilized "biomimetic" ligands. Synthesis, immobilization and chromatographic assessment of an immunoglobulin G-binding ligand.

J. Chromatogr. B. Biomed. Sci. Appl. 740(1) , 1-15, (2000)

A synthetic bifunctional ligand (22/8) comprising a triazine scaffold substituted with 3-aminophenol (22) and 4-amino-1-naphthol (8) has been designed, synthesised, characterised and immobilized on ag...