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Dihydro Cyclosporin A

Names

[ CAS No. ]:
59865-15-5

[ Name ]:
Dihydro Cyclosporin A

[Synonym ]:
6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A
<DH-MeBmt>cyclosporin
dihydro-CSA
DIHYDROCYCLOSPORIN A
Dihydrocyclosporin
(3S,6S,9S,12R,15S,18S,21S,24S,30S)-30-Ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
(3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
(3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-]
1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-, (3S,6S,9S,12R,15S,18S,21S,24S,30S)-
Cyclosporin Impurity 10

Biological Activity

[Description]:

Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Zheng ZW, et al. Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A. Parasit Vectors. 2020 Feb 21;13(1):94.  

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
1285.3±65.0 °C at 760 mmHg

[ Melting Point ]:
120-125ºC

[ Molecular Formula ]:
C62H113N11O12

[ Molecular Weight ]:
1204.627

[ Flash Point ]:
731.1±34.3 °C

[ Exact Mass ]:
1203.857056

[ PSA ]:
278.80000

[ LogP ]:
3.67

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.465

[ Storage condition ]:
-20°C

Precursor & DownStream


Related Compounds