Tyramine

Names

[ CAS No. ]:
60-19-5

[ Name ]:
Tyramine

[Synonym ]:
p-b-Aminoethylphenol
P-hydroxy-b-phenylethylamine
Z2R DQ
MFCD00012682
4-Hydroxy phenylethylamine
EINECS 206-446-4
4-hydroxy-Benzeneethanamine
Phenol, p- (2-aminoethyl)-
4-Hydroxy-β-phenylethylamine
4- (2-aminoethyl)-Phenol
p-(2-aminoethyl)-Phenol
α-(4-Hydroxyphenyl)-β-aminoethane
β-(4-Hydroxyphenyl)ethylamine
2-p-Hydroxyphenylethylamine
a-(4-Hydroxyphenyl)-b-aminoethane
p-β-Aminoethylphenol
4-hydroxy-phenethylamine
p-Hydroxy-β-phenethylamine
4-(2-Aminoethyl)phenol
4-(2-aminoethyl)phenol,hydrochloride
b-(4-Hydroxyphenyl)ethylamine
Phenol, 4-(2-aminoethyl)-
P-hydroxy-β-phenylethylamine
Tyramine base
P-hydroxy-b-phenethylamine

Biological Activity

[Description]:

Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Tyramine is normally broken down in your body by an enzyme called MAO (monoamine oxidase)[1].

[References]

[1]. C Brown , et al. The Monoamine Oxidase Inhibitor-Tyramine Interaction. J Clin Pharmacol. 1989 Jun;29(6):529-32.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
325.2±0.0 °C at 760 mmHg

[ Melting Point ]:
253-255 °C(lit.)

[ Molecular Formula ]:
C₈H₁₂ClNO

[ Molecular Weight ]:
137.179

[ Flash Point ]:
119.2±20.4 °C

[ Exact Mass ]:
137.084061

[ PSA ]:
46.25000

[ LogP ]:
0.72

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.577

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ6050000

CHEMICAL NAME :: Phenol, p-(2-aminoethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 60-19-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H11-N-O.Cl-H

MOLECULAR WEIGHT :: 173.66

WISWESSER LINE NOTATION :: Z2R DQ &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 208 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1044 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 2530 umol/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,193,1988

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S36-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NL4375000

[ HS Code ]:
29222900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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