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N-Demethylechitamine

Names

[ CAS No. ]:
60048-88-6

[ Name ]:
N-Demethylechitamine

[Synonym ]:
Methyl (1S,10S,12S,13E,18R)-13-ethylidene-10-hydroxy-18-(hydroxymethyl)-8,15-diazapentacyclo[10.5.1.0.0.0]octadeca-2,4,6-triene-18-carboxylate
13H-3,8a-Methano-1H-azepino[1',2':1,2]pyrrolo[2,3-b]indole-14-carboxylic acid, 4-ethylidene-2,3,4,5,7,8-hexahydro-1-hydroxy-14-(hydroxymethyl)-, methyl ester, (1S,3S,4E,8aS,13aR)-
Methyl (1S,9R,10S,12S,13E)-13-ethylidene-10-hydroxy-18-(hydroxymethyl)-8,15-diazapentacyclo[10.5.1.0.0.0]octadeca-2,4,6-triene-18-carboxylate
13H-3,8a-Methano-1H-azepino[1',2':1,2]pyrrolo[2,3-b]indole-14-carboxylic acid, 4-ethylidene-2,3,4,5,7,8-hexahydro-1-hydroxy-14-(hydroxymethyl)-, methyl ester, (1S,3S,4E,8aS,14R)-

Biological Activity

[Description]:

Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Yuan YX, et al. Two new monoterpenoid indole alkaloids from Alstonia rostrata. Nat Prod Res. 2018 Apr;32(7):844-848.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
559.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H26N2O4

[ Molecular Weight ]:
370.442

[ Flash Point ]:
292.4±30.1 °C

[ Exact Mass ]:
370.189270

[ PSA ]:
82.03000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.673

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds