elmustine
Names
[ CAS No. ]:
60784-46-5
[ Name ]:
elmustine
[Synonym ]:
Hydroxyethyl CNU
CNU-ethanol
1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitroso urea
N-(2-Hydroxyethyl)-N'-(2-chloroethyl)-N'-nitrosourea
N1-(2-hydroxyethyl)-N3-(2-chloroethyl)-N3-nitrosourea
Hecnu
Elmustine
Elmustine [INN]
Elmustinum [Latin]
Elmustina [Spanish]
Chemical & Physical Properties
[ Density]:
1.45g/cm3
[ Melting Point ]:
56°C
[ Molecular Formula ]:
C5H10ClN3O3
[ Molecular Weight ]:
195.60400
[ Exact Mass ]:
195.04100
[ PSA ]:
82.00000
[ LogP ]:
0.30140
[ Index of Refraction ]:
1.549
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YS4986000
- CHEMICAL NAME :
- Urea, 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitroso-
- CAS REGISTRY NUMBER :
- 60784-46-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C5-H10-Cl-N3-O3
- MOLECULAR WEIGHT :
- 195.63
- WISWESSER LINE NOTATION :
- Q2MVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25300 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - ulceration or bleeding from stomach Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 64 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 96 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Lung
- DOSE/DURATION :
- 1 mg/L/1H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 44,87,1977