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Esculentoside B

Names

[ CAS No. ]:
60820-94-2

[ Name ]:
Esculentoside B

[Synonym ]:
EsculentosideB
(2β,3β)-2,23-Dihydroxy-30-methoxy-30-oxo-3-(β-D-xylopyranosyloxy)olean-12-en-28-oic acid
Olean-12-ene-28,30-dioic acid, 2,23-dihydroxy-3-(β-D-xylopyranosyloxy)-, 30-methyl ester, (2β,3β)-

Biological Activity

[Description]:

Esculentoside B (Phytolaccoside B) is a natural product from the roots of Phytolacca acinosa Roxb. Esculentoside B is neurotoxic to zebrafish larvae, and impairs their central nervous system development. Esculentoside B inhibits inflammatory response and has antifungal activity[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease
Signaling Pathways >> MAPK/ERK Pathway >> JNK
Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Abekura F, et al. Esculentoside B inhibits inflammatory response through JNK and downstream NF-κB signaling pathway in LPS-triggered murine macrophage RAW 264.7 cells. Int Immunopharmacol. 2019;68:156-163.  

[2]. Ren S, et al. Metabolic exploration of the developmental abnormalities and neurotoxicity of Esculentoside B, the main toxic factor in Phytolaccae radix. Food Chem Toxicol. 2023;176:113777.  

[3]. Escalante A, et al. Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. J Nat Prod. 2008;71(10):1720-1725.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
779.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C36H56O11

[ Molecular Weight ]:
664.82

[ Flash Point ]:
237.0±26.4 °C

[ Exact Mass ]:
664.382263

[ PSA ]:
183.21000

[ LogP ]:
5.47

[ Vapour Pressure ]:
0.0±6.1 mmHg at 25°C

[ Index of Refraction ]:
1.600

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds