methopromazine
Names
[ CAS No. ]:
61-01-8
[ Name ]:
methopromazine
[Synonym ]:
2-Methoxypromazine
Methopromazinum [INN-Latin]
Neoproma
[3-(2-methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amine
RP 4632
Methoxypromazine
Tentone
2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine
Methopromazine
Tenton
Methopromazin
Metopromazina [INN-Spanish]
Levopromazine
[3-(2-Methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amin
Chemical & Physical Properties
[ Density]:
1.143g/cm3
[ Boiling Point ]:
461.8ºC at 760 mmHg
[ Molecular Formula ]:
C18H22N2OS
[ Molecular Weight ]:
314.44500
[ Flash Point ]:
233.1ºC
[ Exact Mass ]:
314.14500
[ PSA ]:
41.01000
[ LogP ]:
4.31460
[ Index of Refraction ]:
1.603
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO7600000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy
- CAS REGISTRY NUMBER :
- 61-01-8
- LAST UPDATED :
- 198209
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H22-N2-O-S
- MOLECULAR WEIGHT :
- 314.48
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 EO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 730 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 95 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 408 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960