8-Methylquinoline

Names

[ CAS No. ]:
611-32-5

[ Name ]:
8-Methylquinoline

[Synonym ]:
Quinoline,8-methyl
8-methyl quinoline
Quinoline, 8-methyl-
8-Methyl-chinolin
O-Toluquinoline
MFCD00006810
8-Methylquinoline
EINECS 210-264-0
Fasudil Impurity 11

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
247.5±0.0 °C at 760 mmHg

[ Melting Point ]:
-80 °C

[ Molecular Formula ]:
C₁₀H₉N

[ Molecular Weight ]:
143.185

[ Flash Point ]:
105.0±0.0 °C

[ Exact Mass ]:
143.073502

[ PSA ]:
12.89000

[ LogP ]:
2.54

[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.625

[ Water Solubility ]:
0.1-0.5 g/100 mL at 17 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC0562000

CHEMICAL NAME :: Quinoline, 8-methyl-

CAS REGISTRY NUMBER :: 611-32-5

BEILSTEIN REFERENCE NO. :: 0111340

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H9-N

MOLECULAR WEIGHT :: 143.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 1 mmol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,217,1991

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38;R68

[ Safety Phrases ]:
S26-S36-S45-S36/37/39

[ RIDADR ]:
2810.0

[ WGK Germany ]:
3

[ RTECS ]:
VC0562000

[ Hazard Class ]:
6.1

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A P450 BM-3 mutant hydroxylates alkanes, cycloalkanes, arenes and heteroarenes.

J. Biotechnol. 88(2) , 167-71, (2001)

P450 monooxygenases from microorganisms, similar to those of eukaryotic mitochondria, display a rather narrow substrate specificity. For native P450 BM-3, no other substrates than fatty acids or an in...

The hepatic metabolism of two methylquinolines.

Carcinogenesis 14(5) , 1041-7, (1993)

The hepatic microsomal metabolism of the carcinogenic 8-methylquinoline (8MQ) and its noncarcinogenic isomer, 6-methylquinoline (6MQ), were compared for preparations from control rats and rats pretrea...

Carcinogenicity of quinoline, 4- and 8-methylquinoline and benzoquinolines in newborn mice and rats.

Food Chem. Toxicol. 26(7) , 625-9, (1988)

The relative tumorigenic activity of quinoline, 4-methylquinoline, 8-methylquinoline, and all three isomeric benzoquinolines was evaluated in newborn CD-1 mice and Sprague-Dawley rats. In the newborn-...