1N1&VR

Names

[ CAS No. ]:
611-74-5

[ Name ]:
1N1&VR

[Synonym ]:
N,N-dimethylbutylbenzamide
1N1&VR
Dimethylbenzmide
NN-Dimethylbenzamide
Dimethylbenzamide
N,N-Dimethylbenzamide
EINECS 210-279-2
Benzamide,N,N-dimethyl
N,N-dimethyl benzamide
MFCD00008320
Benzamide, N,N-dimethyl-

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
256.1±9.0 °C at 760 mmHg

[ Melting Point ]:
43-45 °C(lit.)

[ Molecular Formula ]:
C₉H₁₁NO

[ Molecular Weight ]:
149.190

[ Flash Point ]:
111.9±9.9 °C

[ Exact Mass ]:
149.084061

[ PSA ]:
20.31000

[ LogP ]:
0.44

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.529

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV4500000

CHEMICAL NAME :: Benzamide, N,N-dimethyl-

CAS REGISTRY NUMBER :: 611-74-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H11-N-O

MOLECULAR WEIGHT :: 149.21

WISWESSER LINE NOTATION :: 1N1&VR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,20,1971

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CV4500000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

The formation and metabolism of N-hydroxymethyl compounds--III. The metabolic conversion of N-methyl and N,N,-dimethylbenzamides to N-hydroxymethyl compounds.

Biochem. Pharmacol. 32(11) , 1773-81, (1983)

The stability of metabolically-generated N-(hydroxymethyl) compounds was investigated using a series of N-methylbenzamides as model substrates. N-(Hydroxymethyl)-benzamide was characterized as a major...

Hydrotropic polymer micelles as versatile vehicles for delivery of poorly water-soluble drugs.

J. Control. Release 152(1) , 13-20, (2011)

Polymer micelles have been used widely for delivery of poorly water-soluble drugs. Such drug delivery, however, has been based primarily on hydrophobic interactions. For better drug loading and improv...

Hydrotropic solubilization of poorly water-soluble drugs.

J. Pharm. Sci. 99(9) , 3953-65, (2010)

The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. Th...