3-Amino-5-pyrazolone

Names

[ Name ]:
3-Amino-5-pyrazolone

[Synonym ]:
5-Amino-1,2-dihydro-3H-pyrazol-3-one
3-amino-5-pyrazole
(−)-Selagine
5-Amino-1,2-dihydro-pyrazol-3-on
Huperzine A
3-aminopyrazol-5-one
5-Amino-3-hydroxy-1H-pyrazole
3-Amino-1H-pyrazol-5(4H)-one
(-)-Huperzine A
3-Amino-3-pyrazolin-5-one
3-amino-5-pyrazolinone
3-aminopyrazolin-5-one
5-AMINO-3-PYRAZOLOL
5-amino-1,2-dihydro-pyrazol-3-one
EINECS 228-095-6
3-amino-5-oxo-4,5-dihydropyrazole
5-amino-3-pyrazolone
5-Amino-1H-pyrazol-3(2H)-one
3-amino-pyrazol-2-en-5-one
3-Amino-1H-pyrazol-5-ol
5-amino-1,2-dihydropyrazol-3-one
5-AMINOPYRAZOL-3-OL
(−)-Huperzine A
5-amino-3-pyrrazolone
MFCD00022384
3-amino-5-oxopyrazoline
3-Amino-5-pyrazolone
3H-Pyrazol-3-one, 5-amino-1,2-dihydro-

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
479.5±25.0 °C at 760 mmHg

[ Melting Point ]:
214 °C (dec.)(lit.)

[ Molecular Formula ]:
C₃H₅N₃O

[ Molecular Weight ]:
99.091

[ Flash Point ]:
243.8±23.2 °C

[ Exact Mass ]:
99.043259

[ PSA ]:
74.93000

[ LogP ]:
-0.22

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.741

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis of 2,6-difluoro-N-(3-[11C]methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide as a new potential PET agent for imaging of B-Raf(V600E) in cancers.

Bioorg. Med. Chem. Lett. 23(4) , 1017-21, (2013)

The authentic standard 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide was synthesized from 2,6-difluorobenzoic acid and 3-amino-5-hydroxypyrazole in 9 steps...

One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones.

J. Comb. Chem. 12(4) , 600-3, (2010)

A new concise, facile, and efficient method for the synthesis of 3-hydroxy-5,6-diphenylpyrazolo[3,4-b]pyridine derivatives has been described. The cyclocondensation of isoflavones with 3-amino-5-hydro...

Molecular structure and vibrational spectra of 3-amino-5-hydroxypyrazole by density functional method.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 71(5) , 1776-82, (2009)

In this work, we report a combined experimental and theoretical study on molecular and vibrational structure of 3-amino-5-hydroxypyrazole (3A5HP). The Fourier transform infrared and Fourier transform ...