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SM 16

Names

[ CAS No. ]:
614749-78-9

[ Name ]:
SM 16

Biological Activity

[Description]:

SM 16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Research Areas >> Inflammation/Immunology
Research Areas >> Cancer
Research Areas >> Cardiovascular Disease

[Target]

ALK5[1]


[References]

[1]. Suzuki E, et al. A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 2007 Mar 1;67(5):2351-9.

[2]. Fu K, et al. SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71.

[3]. Engebretsen KV, et al. Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. J Mol Cell Cardiol. 2014 Nov;76:148-57.


[Related Small Molecules]

Brigatinib | lorlatinib | Alectinib (CH5424802) | Entrectinib | TAE684(NVP-TAE684) | AZD-3463 | Repotrectinib | Ensartinib | AP26113 | K 02288 | ASP3026 | CEP-37440 | GSK1838705A | Belizatinib

Chemical & Physical Properties

[ Molecular Formula ]:
C25H26N4O3

[ Molecular Weight ]:
430.5

[ Storage condition ]:
2-8℃

Related Compounds