Denosumab

Names

[ Name ]:
Denosumab

Biological Activity

[Description]:

Denosumab is a human monoclonal antibody binding to, and inhibiting, the receptor activator of RANKL (TNFSF11). Denosumab can reduce the risk of vertebral, nonvertebral and hip fractures[1], also has anti-cancer activity[2].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Moen MD, et al. Denosumab: a review of its use in the treatment of postmenopausal osteoporosis. Drugs Aging. 2011;28(1):63-82.

[2]. Chawla S, et al. Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study. Lancet Oncol. 2019;20(12):1719-1729.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₄₀₄H₉₉₁₂N₁₇₂₄O₂₀₀₄S₅₀