OMDM-2

Names

[ Name ]:
OMDM-2

[Synonym ]:
(9Z)-N-[(2R)-1-Hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide
9-Octadecenamide, N-[(1R)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]ethyl]-, (9Z)-
(9Z)-N-[(2R)-1-Hydroxy-3-(4-hydroxyphenyl)-2-propanyl]-9-octadecenamide

Biological Activity

[Description]:

OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki of 3.0 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

Ki: 3.0 μM (anandamide cellular uptake)[1]

[In Vitro]

OMDM-2 shows poor affinity for either CB1 (Ki=5.1 μM) or CB2 (Ki>10 μM) receptors in rat brain and spleen membranes, respectively; OMDM-2 has almost no activity at vanilloid receptors in the intracellular calcium assay carried out with intact cells over-expressing the human VR1 (EC50=10 μM), and no activity as inhibitors of FAAH in N18TG2 cell membranes (Ki>50 μM)[1].

[References]

[1]. Ortar G, et al. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem Pharmacol. 2003 May 1;65(9):1473-81.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
625.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₄₅NO₃

[ Molecular Weight ]:
431.651

[ Flash Point ]:
332.3±31.5 °C

[ Exact Mass ]:
431.339935

[ LogP ]:
7.76

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.518

OMDM-2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds