2-(3-(2-CHLOROETHYL)3-NITROSOUREIDO) ETHYL METHANE SULFONATE
Names
[ CAS No. ]:
61866-12-4
[ Name ]:
2-(3-(2-CHLOROETHYL)3-NITROSOUREIDO) ETHYL METHANE SULFONATE
[Synonym ]:
Cnuems
1-(2-Chloroethyl)-3-(2-methylsulfonyloxyethyl)-1-nitrosourea
1-(2-methanesulfonyloxyethyl)-3-(2-chloroethyl)-3-nitroso urea
Methanesulfonic acid,2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl ester
2-(3-(2-Chloroethyl)3-nitrosoureido)ethyl methane sulfonate
Urea,N-(2-chloroethyl)-N'-(2-((methylsulfonyl)oxy)ethyl)-N-nitroso
Ethylmethanesulfonato-cnu
2-(3-(2-Chlorathyl)-3-nitrosoureido)athylmethansulfonat [German]
Chemical & Physical Properties
[ Density]:
1.52g/cm3
[ Molecular Formula ]:
C6H12ClN3O5S
[ Molecular Weight ]:
273.69500
[ Exact Mass ]:
273.01900
[ PSA ]:
113.52000
[ LogP ]:
1.36610
[ Index of Refraction ]:
1.554
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PB1800000
- CHEMICAL NAME :
- Methanesulfonic acid, 2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl ester
- CAS REGISTRY NUMBER :
- 61866-12-4
- LAST UPDATED :
- 198806
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C5-H10-Cl-N3-O5-S
- MOLECULAR WEIGHT :
- 259.69
- WISWESSER LINE NOTATION :
- WS1&O1MVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13800 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - ulceration or bleeding from stomach Blood - changes in bone marrow (not otherwise specified)
MUTATION DATA
- TYPE OF TEST :
- Gene conversion and mitotic recombination
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 500 umol/L/16H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,45,1977
Safety Information
[ HS Code ]:
2924199090
Customs
[ HS Code ]: 2924199090
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%