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AZD5904

Names

[ CAS No. ]:
618913-30-7

[ Name ]:
AZD5904

[Synonym ]:
6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo-
3-[(2R)-Tetrahydro-2-furanylmethyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
AZD5904

Biological Activity

[Description]:

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

IC50: 140 nM (human MPO)[1]


[In Vitro]

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%[1].

[References]

[1]. Myeloperoxidase (MPO) inhibitor.


[Related Small Molecules]

RSL3 | PF-06282999 | Tinoridine hydrochloride | Verdiperstat

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C10H12N4O2S

[ Molecular Weight ]:
252.293

[ Exact Mass ]:
252.068100

[ LogP ]:
-1.43

[ Index of Refraction ]:
1.704

[ Storage condition ]:
2-8℃

Related Compounds