(4-Bromophenyl)hydrazine hydrochloride
Names
[ CAS No. ]:
622-88-8
[ Name ]:
(4-Bromophenyl)hydrazine hydrochloride
[Synonym ]:
4-Bromo Phenyl Hydrazine Hydrochloride
(4-Bromophenyl)hydrazine hydrochloride (1:1)
Hydrazine, (4-bromophenyl)-, hydrochloride (1:1)
4-Bromophenylhydrazine hydrochloride
(4-bromophenyl)hydrazine hydrochloride
(4-Bromphenyl)hydrazinhydrochlorid
Hydrazine, (p-bromophenyl)-, monohydrochloride (8CI)
4-Bromophenylhydrazinehydrochloride
MFCD00012941
EINECS 255-590-4
Chemical & Physical Properties
[ Boiling Point ]:
285.6ºC at 760 mmHg
[ Melting Point ]:
220-230 °C (dec.)(lit.)
[ Molecular Formula ]:
C6H8BrClN2
[ Molecular Weight ]:
223.498
[ Flash Point ]:
126.5ºC
[ Exact Mass ]:
221.955933
[ PSA ]:
38.05000
[ LogP ]:
3.31000
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MV0800000
- CHEMICAL NAME :
- Hydrazine, 1-(p-bromophenyl)-, hydrochloride
- CAS REGISTRY NUMBER :
- 622-88-8
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C6-H7-Br-N2.Cl-H
- MOLECULAR WEIGHT :
- 223.52
- WISWESSER LINE NOTATION :
- ZMR DE &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
C:Corrosive;
[ Risk Phrases ]:
R34
[ Safety Phrases ]:
S26-S36/37/39-S45-S28A
[ RIDADR ]:
UN 3261 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
MV0800000
[ Hazard Class ]:
8.0
[ HS Code ]:
29280090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2928000090
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
Eur. J. Med. Chem. 40(7) , 655-61, (2005)
The introduction of side chains bearing epoxide motifs into the molecular scaffold of kenpaullone and 9-trifluoromethylpaullone led to improved antiproliferative activity of the novel derivatives for ...
Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor.Bioorg. Med. Chem. Lett. 18(6) , 1926-30, (2008)
A series of novel acylsulfonamide, acylsulfamide, and sulfonylurea bioisosteres of carboxylic acids were prepared as CXCR2 antagonists. Structure-activity relationships are reported for these series. ...