JLK 6

Names

[ Name ]:
JLK 6

[Synonym ]:
7-amino-3-methoxy-4-chloroisocoumarin
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
7-Amino-4-chlor-3-methoxyisocumarin
3-methoxy-4-chloro-7-aminoisocoumarin
7-amino-4-chloro-3-methoxy-isochromen-1-one

Biological Activity

[Description]:

JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Marine Peuchmaur, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21(4):1018-29.

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
456.1ºC at 760 mmHg

[ Melting Point ]:
115 °C

[ Molecular Formula ]:
C₁₀H₈ClNO₃

[ Molecular Weight ]:
225.62800

[ Flash Point ]:
229.7ºC

[ Exact Mass ]:
225.01900

[ PSA ]:
65.46000

[ LogP ]:
2.61840

[ Index of Refraction ]:
1.628

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%