CHLOROETHYL CHLOROFORMATE

Names

[ CAS No. ]:
627-11-2

[ Name ]:
CHLOROETHYL CHLOROFORMATE

[Synonym ]:
2-Chlorethylchlorocarbonat
2-Chloroethyl chloroformate
1-Chloroethyl chloroformate
1-Chloroethyl carbonochloridate
α-Chloroethyl chloroformate
MFCD00000646
Carbonochloridic acid, 2-chloroethyl ester
2-Chloroethyl carbonochloridate
CHLOROETHYL CHLOROFORMATE
Carbonochloridic acid, 1-chloroethyl ester
EINECS 210-982-4

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
156.9±13.0 °C at 760 mmHg

[ Melting Point ]:
-70ºC BOLING

[ Molecular Formula ]:
C₃H₄Cl₂O₂

[ Molecular Weight ]:
142.969

[ Flash Point ]:
59.8±15.2 °C

[ Exact Mass ]:
141.958832

[ PSA ]:
26.30000

[ LogP ]:
1.51

[ Vapour Pressure ]:
2.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.439

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ5950000

CHEMICAL NAME :: Formic acid, chloro-, 2-chloroethyl ester

CAS REGISTRY NUMBER :: 627-11-2

BEILSTEIN REFERENCE NO. :: 0506639

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C3-H4-Cl2-O2

MOLECULAR WEIGHT :: 142.97

WISWESSER LINE NOTATION :: GVO2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,JUN1942

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H331

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
3277

[ RTECS ]:
LQ5950000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Asymmetric synthesis of the 4-hydroxymethyl-2-oxazolidinone from the serinol derivative and chloroformates. Sugiyama S, et al.

Tetrahedron Lett. 40(42) , 7489-92, (1999)

A new approach to pyrrolophenanthridone alkaloids via allene intramolecular cycloaddition: Total synthesis of Hippadine. Hayakawa K, et al.

Tetrahedron Lett. 28(47) , 5895-98, (1987)

Enzymatic resolution of new carbonate intermediates for the synthesis of (< i> S</i>)-(+)-zopiclone. Solares LF, et al.

Tetrahedron Asymmetry 13(23) , 2577-82, (2002)