N-Ethylformamide
Names
[ CAS No. ]:
627-45-2
[ Name ]:
N-Ethylformamide
[Synonym ]:
EINECS 211-001-2
N-formylethylamine
monoethyl-formamide
Ethylformamide
MFCD00042672
N-ethyl carboxamide
N-ethyl-formamide
Formamide,N-ethyl
N-Aethylformamid [German]
Chemical & Physical Properties
[ Density]:
0.950 g/mL at 20ºC(lit.)
[ Boiling Point ]:
202-204ºC
[ Melting Point ]:
-60.43°C (estimate)
[ Molecular Formula ]:
C3H7NO
[ Molecular Weight ]:
73.09380
[ Flash Point ]:
67ºC
[ Exact Mass ]:
73.05280
[ PSA ]:
29.10000
[ LogP ]:
0.77910
[ Index of Refraction ]:
n20/D 1.432
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LQ2725000
- CHEMICAL NAME :
- Formamide, N-ethyl-
- CAS REGISTRY NUMBER :
- 627-45-2
- BEILSTEIN REFERENCE NO. :
- 1737860
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C3-H7-N-O
- MOLECULAR WEIGHT :
- 73.11
- WISWESSER LINE NOTATION :
- VHM2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,645,1968
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,873,1972
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Safety Phrases ]:
S23-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
LQ2725000
[ HS Code ]:
2924199090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924199090
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Br. J. Cancer 45(6) , 843-50, (1982)
The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In...
Cloning and expression of rat CYP2E1 in Saccharomyces cerevisiae: detection of genotoxicity of N-alkylformamides.Environ. Mol. Mutagen. 36(2) , 97-104, (2000)
A cDNA coding for rat cytochrome P450 2E1 was cloned into the multicopy vector pYeDP60 and expressed in haploid RSY6 and diploid RS112 yeast strains of Saccharomyces cerevisiae under control of the GA...
An investigation of the relationship between the hepatotoxicity and the metabolism of N-alkylformamides.J. Pharmacol. Exp. Ther. 240(1) , 265-70, (1987)
The hepatotoxicity and metabolism of the following close analogs of the hepatotoxic antitumor agent N-methylformamide (NMF) were investigated in CBA/CA mice: N-ethylformamide (NEF), dimethylformamide ...