Fumaryl chloride
Names
[ CAS No. ]:
627-63-4
[ Name ]:
Fumaryl chloride
[Synonym ]:
n-Butyl fumarate
fumaroyl chloride
MFCD00000733
Fumarsaeure-mono-n-butylester
fumaroyl dichloride
EINECS 211-005-4
fumaric acid chloroanhydride
Fumaric acid dichloride
Monobutyl fumarate
fumaric acid dichloroanhydride
mono-n-butyl maleate
Fumaric acid,butyl ester
Fumaric acid monobutyl ester
but-2-enedioyl dichloride
Chemical & Physical Properties
[ Density]:
1.415 g/mL at 25 °C(lit.)
[ Boiling Point ]:
161-164 °C(lit.)
[ Melting Point ]:
-2 °C
[ Molecular Formula ]:
C4H2Cl2O2
[ Molecular Weight ]:
152.96300
[ Flash Point ]:
165 °F
[ Exact Mass ]:
151.94300
[ PSA ]:
34.14000
[ LogP ]:
1.07340
[ Index of Refraction ]:
n20/D 1.499(lit.)
[ Storage condition ]:
Refrigerator (+4°C)
[ Water Solubility ]:
decomposes
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LT2800000
- CHEMICAL NAME :
- Fumaryl chloride
- CAS REGISTRY NUMBER :
- 627-63-4
- BEILSTEIN REFERENCE NO. :
- 1721342
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C4-H2-Cl2-O2
- MOLECULAR WEIGHT :
- 152.96
- WISWESSER LINE NOTATION :
- GV1U1VG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,327,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,327,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 810 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1000 mg/m3/10M
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Musculoskeletal - other changes
- REFERENCE :
- NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,MAY1942
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1410 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302 + H312 + H332-H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive;
[ Risk Phrases ]:
R20/21/22;R29;R34
[ Safety Phrases ]:
S26-S36/37/39-S45-S8
[ RIDADR ]:
UN 1780 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
LT2800000
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
29171990
Synthetic Route
Customs
[ HS Code ]: 2917190090
[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
J. Biomater. Sci. Polym. Ed. 10(3) , 363-73, (1999)
To synthesize high molecular weight poly(propylene fumarate) (PPF), fumaryl chloride and propylene glycol were reacted in the presence of potassium carbonate, which serves as a proton scavenger. Trans...
Dynamics of Cl (2Pj) atom formation in the photodissociation of fumaryl chloride (ClCO - CH = CH - COCl) at 235 nm: a resonance enhanced multiphoton ionization (REMPI) time-of-flight (TOF) study.J. Phys. Chem. A 115(9) , 1538-46, (2011)
The photodissociation dynamics of fumaryl chloride (ClCO-CH═CH-COCl) has been studied in a supersonic molecular beam around 235 nm using resonance enhanced multiphoton ionization (REMPI) time-of-fligh...
Synthesis of oligo(poly(ethylene glycol) fumarate).Nat. Protoc. 7(6) , 1219-27, (2012)
This protocol describes the synthesis of oligo(poly(ethylene glycol) fumarate) (OPF; 1-35 kDa; a polymer useful for tissue engineering applications) by a one-pot reaction of poly(ethylene glycol) (PEG...