thonzylamine hydrochloride

Names

[ CAS No. ]:
63-56-9

[ Name ]:
thonzylamine hydrochloride

[Synonym ]:
Novohetramin
Thonzylaminium chloride
N,N-Dimethyl-N'-(p-methoxybenzyl)-N'-(2-pyrimidyl)ethylenediamine Hydrochloride
Anahist
N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyrimidinyl-1,2-ethanediamineMonohydrochloride
EINECS 200-561-3
Thonzylamine HCl
1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N-2-pyrimidinyl-, hydrochloride (1:1)
UNII-6K9YKD48Y4
THONZYLAMINE HYDROCHLORIDE
N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(2-pyrimidinyl)-1,2-ethanediamine hydrochloride (1:1)
N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine hydrochloride
N-(4-methoxybenzyl)-N',N'-dimethyl-N-(pyrimidin-2-yl)ethane-1,2-diamine hydrochloride (1:1)
Resistab
Neohetramine hydrochloride
2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyrimidine hydrochloride

Chemical & Physical Properties

[ Density]:
1.2562 (rough estimate)

[ Boiling Point ]:
bp2.2 185-187°

[ Melting Point ]:
173 - 176ºC

[ Molecular Formula ]:
C₁₆H₂₃ClN₄O

[ Molecular Weight ]:
322.833

[ Flash Point ]:
220.3ºC

[ Exact Mass ]:
322.156036

[ PSA ]:
41.49000

[ LogP ]:
2.85540

[ Index of Refraction ]:
1.5800 (estimate)

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8750000

CHEMICAL NAME :: Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, hydrochloride

CAS REGISTRY NUMBER :: 63-56-9

LAST UPDATED :: 198812

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H22-N4-O.Cl-H

MOLECULAR WEIGHT :: 322.88

WISWESSER LINE NOTATION :: T6N CNJ BN1R DO1&2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,419,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 157 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,83S,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 493 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 38200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,313,1958 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
36