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1,2,3,4-tetrachlorobenzene

Names

[ CAS No. ]:
634-66-2

[ Name ]:
1,2,3,4-tetrachlorobenzene

[Synonym ]:
MFCD00000538
1,2,3,4-TeCB
1,2,3,4-tcb
1,2,3,4-Tetrachlorobenzene
2,3,4,5-tetrachlorobenzene
Tetrachlorobenzene
1,2,3,4,-tetrachlorobenzene
EINECS 211-214-0
1,2,3,4-tetrachloro-benzen
1,2,3,4-tetraclorobenzene
Tetrachlorobenzene,1,2,3,4
BENZENE,1,2,3,4-TETRACHLORO

Chemical & Physical Properties

[ Density]:
1,73 g/cm3

[ Boiling Point ]:
254 °C761 mm Hg(lit.)

[ Melting Point ]:
44 °C

[ Molecular Formula ]:
C6H2Cl4

[ Molecular Weight ]:
215.89200

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
213.89100

[ LogP ]:
4.30020

[ Index of Refraction ]:
1.582

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB9440000
CHEMICAL NAME :
Benzene, 1,2,3,4-tetrachloro-
CAS REGISTRY NUMBER :
634-66-2
BEILSTEIN REFERENCE NO. :
1910025
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C6-H2-Cl4
MOLECULAR WEIGHT :
215.88
WISWESSER LINE NOTATION :
GR BG CG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1167 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 11,663,1983
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 4,106,1952 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29,21,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
female 9-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 26,243,1983

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25-S45-S16-S7-S36/37

[ RIDADR ]:
3077

[ WGK Germany ]:
3

[ RTECS ]:
DB9440000

[ Hazard Class ]:
9.0

Synthetic Route

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QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

Determination of chlorobenzenes in water samples by solid-phase disk extraction and gas chromatography-electron capture detection.

J. Chromatogr. Sci. 52(5) , 375-82, (2014)

A simple, rapid, sensitive and high throughput method is described, based on solid-phase disk extraction (SPDE) and gas chromatography-electron capture detection, for the determination of chlorobenzen...

Chlorocatechols substituted at positions 4 and 5 are substrates of the broad-spectrum chlorocatechol 1,2-dioxygenase of Pseudomonas chlororaphis RW71.

J. Bacteriol. 183(3) , 997-1011, (2001)

The nucleotide sequence of a 10,528-bp region comprising the chlorocatechol pathway gene cluster tetRtetCDEF of the 1,2,3,4-tetrachlorobenzene via the tetrachlorocatechol-mineralizing bacterium Pseudo...


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