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N(delta)-(N-methyl-N-nitrosocarbamoyl)-L-ornithine

Names

[ CAS No. ]:
63642-17-1

[ Name ]:
N(delta)-(N-methyl-N-nitrosocarbamoyl)-L-ornithine

[Synonym ]:
N(sup 5)-(Methylnitrosocarbamoyl)-L-ornithine
N-(N-Methyl-N-nitrosocarbamoyl)-l-ornithine
n5-[methyl(nitroso)carbamoyl]-l-ornithine
L-Ornithine,N(5)-((methylnitrosoamino)carbonyl)
N5-((Methylnitrosoamino)carbonyl)-L-ornithine
MNCO

Chemical & Physical Properties

[ Molecular Formula ]:
C7H14N4O4

[ Molecular Weight ]:
218.21000

[ Exact Mass ]:
218.10200

[ PSA ]:
128.58000

[ LogP ]:
0.40600

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RM2983000
CHEMICAL NAME :
L-Ornithine, N(sup 5)-(N-methyl-N-nitrosocarbamoyl)-,
CAS REGISTRY NUMBER :
63642-17-1
LAST UPDATED :
199310
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C7-H14-N4-O4
MOLECULAR WEIGHT :
218.25
WISWESSER LINE NOTATION :
QVYZ3MVN1&NO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1870 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
2616 mg/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
3924 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
1308 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
DNA damage

MUTATION DATA

TEST SYSTEM :
Rodent - hamster
DOSE/DURATION :
25 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1033,1987 *** REVIEWS *** TOXICOLOGY REVIEW APLMAS Archives of Pathology and Laboratory Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-5(2), 1926-28; V.100- 1976- Volume(issue)/page/year: 107,54,1983

Safety Information

[ HS Code ]:
2924199090

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds