Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
Names
[ CAS No. ]:
63989-75-3
[ Name ]:
Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
[Synonym ]:
N-Benzoyltrimethylcolchicinsaeuremethylaether
N-Benzoyl-deacetylcolchicine
Colchicine,N-benzoyl-N-deacetyl
N-Benzoyl trimethyl colchicinic acid methyl ether
N-Benzoyl tmca methyl ether
COLCHICINE,N-DEACETYL-N-BENZOYL
N-benzoyl-N-deacetylcolchicine
Chemical & Physical Properties
[ Density]:
1.28g/cm3
[ Boiling Point ]:
780.3ºC at 760 mmHg
[ Molecular Formula ]:
C27H27NO6
[ Molecular Weight ]:
461.50600
[ Flash Point ]:
425.7ºC
[ Exact Mass ]:
461.18400
[ PSA ]:
83.09000
[ LogP ]:
4.55640
[ Index of Refraction ]:
1.62
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0790000
- CHEMICAL NAME :
- Colchicine, N-deacetyl-N-benzoyl-
- CAS REGISTRY NUMBER :
- 63989-75-3
- BEILSTEIN REFERENCE NO. :
- 3184511
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C27-H27-N-O6
- MOLECULAR WEIGHT :
- 461.55
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMVR& NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27924 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 12500 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- REFERENCE :
- CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950