Aminotrimethylene phosphonic acid

Names

[ Name ]:
Aminotrimethylene phosphonic acid

[Synonym ]:
Aminotri(methylene phosphonic acid)
nitrilotrimethylenephosphonic acid
N,N,N-triphosphonomethyl amine
Aminotris(methylphosphonic acid)
[Nitrilotris(methylene)]tris(phosphonic acid)
N_Tf
(Nitrilotris(methylene))triphosphonic acid
ATMP
ferrofos509
ATMPA
(nitrilotrimethanediyl)tris(phosphonic acid)
UNII-1Y702GD0FG
dowelll37
ntpo
Dequest 2000
BRIQUEST 301-50A
Aminotris(methanephosphonic acid)
Briquest 301
EINECS 229-146-5
MFCD00002138
Amino tris(methylene phosphonic acid)
Phosphonic acid, [nitrilotris(methylene)]tris-
Amino tris (methylene phosphonic acid)

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
746.2±70.0 °C at 760 mmHg

[ Melting Point ]:
~215 °C (dec.)

[ Molecular Formula ]:
C₃H₁₂NO₉P₃

[ Molecular Weight ]:
299.050

[ Flash Point ]:
405.1±35.7 °C

[ Exact Mass ]:
298.972504

[ PSA ]:
205.26000

[ LogP ]:
-4.63

[ Vapour Pressure ]:
0.0±5.4 mmHg at 25°C

[ Index of Refraction ]:
1.610

[ Stability ]:
Stable. Incompatible with bases, strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ9860000

CHEMICAL NAME :: Phosphonic acid, (nitrilotris(methylene))tri-

CAS REGISTRY NUMBER :: 6419-19-8

BEILSTEIN REFERENCE NO. :: 1715724

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C3-H12-N-O9-P3

MOLECULAR WEIGHT :: 299.07

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(2),67,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >6310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >2510 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >2510 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0990-0937 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1302 mg/kg/31D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in sodium

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(2),67,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1717 No. of Facilities: 72 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 1279 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1717 No. of Facilities: 2426 (estimated) No. of Industries: 57 No. of Occupations: 33 No. of Employees: 38609 (estimated) No. of Female Employees: 2280 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S45-S36/37/39-S25

[ RIDADR ]:
3265

[ WGK Germany ]:
1

[ RTECS ]:
SZ9860000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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Proc. Natl. Acad. Sci. U. S. A. 104 , 12282-7, (2007)

Conjugative transfer of plasmid DNA via close cell-cell junctions is the main route by which antibiotic resistance genes spread between bacterial strains. Relaxases are essential for conjugative trans...

Determination of phosphonates in natural waters by ion-pair high-performance liquid chromatography.

J. Chromatogr. A. 773(1-2) , 139-46, (1997)

The paper describes a new method for the determination of phosphonates by ion-pair high-performance liquid chromatography. The phosphonates are complexed with Fe(III) and separated on a reversed-phase...

Adsorptive removal of nitrilotris(methylenephosphonic acid) antiscalant from membrane concentrates by iron-coated waste filtration sand.

J. Hazard. Mater. 182(1-3) , 855-62, (2010)

Iron-coated waste filtration sand was investigated as a low-cost adsorbent for the removal of nitrilotris(methylenephosphonic acid) (NTMP) from membrane concentrates. The adsorption of this phosphonat...