3-NITROBENZAMIDE

Names

[ CAS No. ]:
645-09-0

[ Name ]:
3-NITROBENZAMIDE

[Synonym ]:
MFCD00007984
EINECS 211-431-0
3-nitrobenzamide

Chemical & Physical Properties

[ Density]:
1.431g/cm3

[ Boiling Point ]:
310 - 315ºC

[ Melting Point ]:
140-143 °C(lit.)

[ Molecular Formula ]:
C₇H₆N₂O₃

[ Molecular Weight ]:
166.13400

[ Flash Point ]:
145.852ºC

[ Exact Mass ]:
166.03800

[ PSA ]:
88.91000

[ LogP ]:
1.91720

[ Index of Refraction ]:
1.618

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV5601250

CHEMICAL NAME :: Benzamide, 3-nitro-

CAS REGISTRY NUMBER :: 645-09-0

BEILSTEIN REFERENCE NO. :: 0777185

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H6-N2-O3

MOLECULAR WEIGHT :: 166.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 28,335,1994

Safety Information

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CV5601250

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Novel inhibitors of poly(ADP-ribose) synthetase.

Biochem. J. 185 , 775-777, (1980)

In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. T...

Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.

J. Biol. Chem. 257(11) , 6084-8, (1982)

We have shown previously that alloxan and streptozotocin, two major diabetogenic agents, cause DNA strand breaks in rat pancreatic islets and stimulate nuclear poly(ADP-ribose) synthetase, thereby dep...