3-HYDROXYMETHYL-BETA-CARBOLINE

Names

[ CAS No. ]:
65474-79-5

[ Name ]:
3-HYDROXYMETHYL-BETA-CARBOLINE

[Synonym ]:
3-HMC
9H-Pyrido[3,4-b]indole-3-methanol
Prestwick_970

Chemical & Physical Properties

[ Density]:
1.385 g/cm3

[ Boiling Point ]:
466ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₀N₂O

[ Molecular Weight ]:
198.22100

[ Flash Point ]:
235.6ºC

[ Exact Mass ]:
198.07900

[ PSA ]:
48.91000

[ LogP ]:
2.20840

[ Index of Refraction ]:
1.795

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Do benzodiazepine receptors play a role in sleep regulation? Studies with the benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline (3-HMC).

Prog. Clin. Biol. Res. 90 , 253-61, (1982)

Electrophysiological studies on benzodiazepine antagonists.

Brain Res. 295(2) , 265-74, (1984)

The actions of the benzodiazepine (BDZ) antagonists 3-hydroxymethyl-beta-carboline (3-HMC), Ro 14-7437 and Ro 15-1788 were tested on single cell activity of rat hypothalamic neurons in tissue cultures...

The interaction between benzodiazepine antagonists and barbiturate-induced cerebrovascular and cerebral metabolic depression.

Neuropharmacology 24(10) , 957-63, (1985)

It has been reported that pentobarbital facilities binding to benzodiazepine receptors binding at anesthetic concentrations and that this action may play a role in the anesthetic potency of this barbi...