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Carbamic acid,N-butyl-N-nitroso-, ethyl ester

Names

[ CAS No. ]:
6558-78-7

[ Name ]:
Carbamic acid,N-butyl-N-nitroso-, ethyl ester

[Synonym ]:
N-Nitroso-N-butyl-urethan
N-Butyl-N-nitrosourethan
N-Butyl-N-nitrosourethane
butyl-nitroso-carbamic acid ethyl ester
N-n-Butyl-N-nitroso-urethan
N-Nitrosobutylurethane
1-Butyl-1-nitrosourethan
N-Nitroso-butylurethan
BNUR
TL 478
Butyl-nitroso-carbamidsaeure-aethylester
N-Butyl-N-nitroso ethyl carbamate
N-n-Butyl-N-nitrosourethane

Chemical & Physical Properties

[ Density]:
1.08g/cm3

[ Boiling Point ]:
207.3ºC at 760 mmHg

[ Molecular Formula ]:
C7H14N2O3

[ Molecular Weight ]:
174.19800

[ Flash Point ]:
79.2ºC

[ Exact Mass ]:
174.10000

[ PSA ]:
58.97000

[ LogP ]:
1.92640

[ Index of Refraction ]:
1.468

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EZ1275000
CHEMICAL NAME :
Carbamic acid, N-butyl-N-nitroso-, ethyl ester
CAS REGISTRY NUMBER :
6558-78-7
BEILSTEIN REFERENCE NO. :
1780198
LAST UPDATED :
199612
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C7-H14-N2-O3
MOLECULAR WEIGHT :
174.23
WISWESSER LINE NOTATION :
ONN4&VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg female 20 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Endocrine - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2240 mg/kg/8W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg female 15-21 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Reproductive - Tumorigenic effects - testicular tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5300 mg/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5040 mg/kg/18W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
5 gm/kg/16W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg/16W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
100 umol/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 58,1635,1977

Safety Information

[ HS Code ]:
2928000090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%


Related Compounds