1b-D-Arabinofuranosyl-5-azacytosine
Names
[ CAS No. ]:
65886-71-7
[ Name ]:
1b-D-Arabinofuranosyl-5-azacytosine
[Synonym ]:
4-Amino-1-(β-D-arabinofuranosyl)-1,3,5-triazin-2(1H)-one
1b-D-Arabinofuranosyl-5-azacytosine
4-Amino-1b-D-arabinofuranosyl-s-triazin-2(1H)-one
Fazarabine
5-azacytosine arabinoside
ara-AC
1-β-D-Arabinofuranosyl-5-azacytosine
4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-arabinofuranosyl-
5-azaaracytidine
Chemical & Physical Properties
[ Density]:
2.1±0.1 g/cm3
[ Boiling Point ]:
534.5±60.0 °C at 760 mmHg
[ Melting Point ]:
228-230ºC (decomposes)
[ Molecular Formula ]:
C8H12N4O5
[ Molecular Weight ]:
244.205
[ Flash Point ]:
277.0±32.9 °C
[ Exact Mass ]:
244.080765
[ PSA ]:
143.72000
[ LogP ]:
-1.99
[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C
[ Index of Refraction ]:
1.823
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XZ2854400
- CHEMICAL NAME :
- s-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl-
- CAS REGISTRY NUMBER :
- 65886-71-7
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H12-N4-O5
- MOLECULAR WEIGHT :
- 244.24
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1557 ug/kg/72H-C
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - agranulocytosis
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,297,1983