BL-140
Names
[ CAS No. ]:
663620-66-4
[ Name ]:
BL-140
Biological Activity
[Description]:
A novel specific p110β inhibitor with IC50 of 5.74 nM; dispalys 150-fold and 745-fold selectivity over p110α or p110δ; blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells.
[References]
References 1. He C, et al. Prostate. 2017 Aug;77(11):1187-1198. View Related Products by Target PI3K
Chemical & Physical Properties
[ Molecular Formula ]:
C18H21N5O2S
[ Molecular Weight ]:
371.459