Roxyl-WL

Names

[ Name ]:
Roxyl-WL

[Synonym ]:
1,2,3-Triazolo[4,5-f][1,2,3]benzotriazole-4,8(1H,5H)-dione, 1,5-bis(phenylmethyl)-
1,5-Dibenzyl[1,2,3]triazolo[4,5-f]benzotriazole-4,8(1H,5H)-dione

Biological Activity

[Description]:

Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM; displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases; effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs), significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally.

[References]

References 1. Xu G, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1089-1094. View Related Products by Target Indoleamine 2,3-Dioxygenase (IDO)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
685.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₄N₆O₂

[ Molecular Weight ]:
370.364

[ Flash Point ]:
368.1±34.3 °C

[ Exact Mass ]:
370.117828

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.783

Roxyl-WL

Names

Biological Activity

Chemical & Physical Properties

Related Compounds