AKCI

Names

[ Name ]:
AKCI

[Synonym ]:
2-Quinazolinamine, 4,8-dimethyl-N-[1,4,5,6-tetrahydro-5-[2-(4-morpholinyl)ethyl]-1,3,5-triazin-2-yl]-
4,8-Dimethyl-N-{5-[2-(4-morpholinyl)ethyl]-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl}-2-quinazolinamine
1,3,5-triazin-2-amine, N-[(2E)-4,8-dimethyl-2(1H)-quinazolinylidene]-1,4,5,6-tetrahydro-5-[2-(4-morpholinyl)ethyl]-

Biological Activity

[Description]:

A small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells; induces G2/M cell-cycle arrest through modulation of the p53/p21/CDC2/cyclin B1 pathways, significantly inhibits MDA-MB-231 cell migration and invasion, as well as decreasing colony formation and tumor growth, decreases PMA-induced activation of NF-κB.

[References]

References 1. Han EH, et al. Oncotarget. 2017 Jun 29;8(41):69691-69708. View Related Products by Target Aurora Kinase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
555.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₇N₇O

[ Molecular Weight ]:
369.464

[ Flash Point ]:
290.0±32.9 °C

[ Exact Mass ]:
369.227722

[ LogP ]:
0.64

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.684