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DSHS00884

Names

[ CAS No. ]:
675104-49-1

[ Name ]:
DSHS00884

Biological Activity

[Description]:

DSHS00884 is a potent human papillomavirus E6 inhibitor with an IC50 of 10 μM[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Filovirus

[Target]

IC50: 10 μM (human papillomavirus E6)[1]


[In Vitro]

DSHS00884 stabilizes p53 levels in HPV-positive cells by blocking E6-mediated p53 degradation with an IC50 of 2.5-25 μM[1].

[References]

[1]. Malecka KA, et al. Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem Biol. 2014 Jul 18;9(7):1603-12.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H12N4O2S2

[ Molecular Weight ]:
308.38


Related Compounds