Sodium DL-Malate

Names

[ CAS No. ]:
676-46-0

[ Name ]:
Sodium DL-Malate

[Synonym ]:
DL-Malic acid disodium salt
Disodium DL-malate
Disodium malate
UNII:2EFF9N315F
Sodium DL-Malate
Butanedioic acid, 2-hydroxy-, sodium salt (1:2)
Hydroxybutanedioic acid disodium salt
MFCD00012466
Butanedioic acid, hydroxy-, disodium salt
disodium 2-hydroxybutanedioate
Sodium malate
EINECS 211-627-6

Biological Activity

[Description]:

Sodium DL-Malate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Boiling Point ]:
306.4ºC at 760 mmHg

[ Melting Point ]:
> 300°C (Lit.)

[ Molecular Formula ]:
C₄H₄Na₂O₅

[ Molecular Weight ]:
178.051

[ Flash Point ]:
153.4ºC

[ Exact Mass ]:
177.985413

[ PSA ]:
100.49000

[ Storage condition ]:
Store below +30°C.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON7730000

CHEMICAL NAME :: Malic acid, sodium salt

CAS REGISTRY NUMBER :: 676-46-0

LAST UPDATED :: 199504

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H4-O5.2Na

MOLECULAR WEIGHT :: 178.06

WISWESSER LINE NOTATION :: QV1YQVO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - excitement Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 25,467,1925

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905- Volume(issue)/page/year: 28,185,1917 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4709 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
ON7730000

[ HS Code ]:
2917190090

Customs

[ HS Code ]: 2917190090

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.

Bioorg. Med. Chem. Lett. 15 , 573-8, (2005)

A detailed inhibition study of five carbonic anhydrase (CA, EC 4.2.1.1) isozymes with carboxylates including aliphatic (formate, acetate), dicarboxylic (oxalate, malonate), hydroxy/keto acids (l-lacta...

GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy.

Am. J. Physiol. Renal Physiol. 304(11) , F1317-24, (2013)

Early diagnosis of diabetic nephropathy (DN) is difficult although it is of crucial importance to prevent its development. To probe potential markers and the underlying mechanism of DN, an animal mode...

In vitro reactive oxygen species production by mitochondria from the rabbitfish Siganus fuscessens livers and the effects of Irgarol-1051.

Environ. Toxicol. Pharmacol. 35(2) , 154-60, (2013)

In this study, the mitochondria from the livers of Siganus fuscessens were exposed to the Irgarol-1051with or without respiratory chain inhibitors using succinate or malate as the substrate, and the e...