Tetrahydro-11-deoxy Cortisol

Names

[ CAS No. ]:
68-60-0

[ Name ]:
Tetrahydro-11-deoxy Cortisol

[Synonym ]:
tetrahydrocortexolone
5beta-Pregnane-3alpha,17alpha,21-triol-20-one
3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-one
EINECS 200-691-0
Tetrahydrodeoxycortisol
Tetrahydro-11-deoxycortisol

Biological Activity

[Description]:

Tetrahydro-11-deoxycortisol (Tetrahydrodeoxycortisol) is an endogenous metabolite present in Urine that can be used for the research of 11 Beta Hydroxylase Deficiency[1][2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Burren CP, et al. CYP11 beta 1 (11-beta-hydroxylase) deficiency in congenital adrenal hyperplasia. J Paediatr Child Health. 1996 Oct;32(5):433-8.

Chemical & Physical Properties

[ Density]:
1.186g/cm3

[ Boiling Point ]:
505.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₄O₄

[ Molecular Weight ]:
350.49200

[ Flash Point ]:
273.4ºC

[ Exact Mass ]:
350.24600

[ PSA ]:
77.76000

[ LogP ]:
2.68250

[ Index of Refraction ]:
1.56

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Study of urinary steroid hormone disorders: difference between hepatocellular carcinoma in early stage and cirrhosis.

Anal. Bioanal. Chem 406(18) , 4325-35, (2014)

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Discovery of novel biomarkers for early HCC from other liver diseases such as cirrhosis is of great clinical benefit. In th...

[Urinary tetrahydro-11-deoxycortisol].

Nihon Rinsho. 68 Suppl 7 , 401-3, (2010)

A quantitative in vivo mouse model used to assay inhibitors of tumor-induced angiogenesis.

Cancer Res. 51(4) , 1339-44, (1991)

An in vivo model of tumor-induced angiogenesis was used to monitor two known inhibitors of angiogenesis, protamine sulfate and the steroid tetrahydro S. Tumor cells entrapped in alginate beads were in...