17α-hydroxyprogesterone

Names

[ CAS No. ]:
68-96-2

[ Name ]:
17α-hydroxyprogesterone

[Synonym ]:
17α-Hydroxypregn-4-ene-3,20-dione
17-Hydroxypregn-4-en-3,20-dione
MFCD00003659
hydroxyprogesteronum [INN_la]
17-Hydroxypregn-4-ene-3,20-dione
4-Pregnen-17a-ol-3,20-dione
4-Pregnen-17α-ol-3,20-dione
17alpha-hydroxyprogesterone
Pregn-4-ene-3,20-dione, 17-hydroxy-
17α-Hydroxyprogesterone
Gestageno
L E5 B666 OV MUTJ A1 E1 FV1 FQ &&17α
EINECS 200-699-4
17a-Hydroxypregn-4-ene-3,20-dione
17A-hydroxyprogesterone
17-Hydroxyprogesterone

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
482.9±45.0 °C at 760 mmHg

[ Melting Point ]:
276°C

[ Molecular Formula ]:
C₂₁H₃₀O₃

[ Molecular Weight ]:
330.461

[ Flash Point ]:
260.0±25.2 °C

[ Exact Mass ]:
330.219482

[ PSA ]:
54.37000

[ LogP ]:
2.89

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.560

[ Storage condition ]:
-20?C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5060000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17-hydroxy-

CAS REGISTRY NUMBER :: 68-96-2

BEILSTEIN REFERENCE NO. :: 2062088

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H30-O3

MOLECULAR WEIGHT :: 330.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 65 mg/kg

SEX/DURATION :: female 8-32 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 26,151,1960

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,18,1956

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
61

[ Safety Phrases ]:
S53-S22-S36/37/39-S45

[ RIDADR ]:
2811.0

[ WGK Germany ]:
3

[ RTECS ]:
TU5060000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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