UNII:EIL57224QR

Names

[ Name ]:
UNII:EIL57224QR

[Synonym ]:
Palmitoyl-L-carnitine chloride
3-carboxy-n,n,n-trimethyl-2-(palmitoyloxy)propan-1-aminium chloride
UNII:EIL57224QR
1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-, chloride (1:1)
3-Carboxy-N,N,N-trimethyl-2-(palmitoyloxy)-1-propanaminium chloride
(±)-Palmitoylcarnitine chloride

Biological Activity

[Description]:

Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca2+ influx, and DHT-like effects[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[References]

[1]. Al-Bakheit A, et al. Accumulation of Palmitoylcarnitine and Its Effect on Pro-Inflammatory Pathways and Calcium Influx in Prostate Cancer. Prostate. 2016 Oct;76(14):1326-37.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₄₆ClNO₄

[ Molecular Weight ]:
436.069

[ Exact Mass ]:
435.311523

[ PSA ]:
63.60000

[ LogP ]:
2.56440

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Modulation by palmitoylcarnitine of protein kinase C activation.

Cancer Res. 47 , 6537-6542, (1987)

Palmitoylcarnitine, a reported protein kinase C inhibitor, enhanced the phorbol ester dependency of the enzyme, augmenting protein kinase C activity in the presence of phorbol esters such as phorbol 1...

Palmitoyl-DL-carnitine has calcium-dependent effects on cultured neurones from rat dorsal root ganglia.

Br. J. Pharmacol. 107 , 1192-1197, (1992)

1. The effects of palmitoyl-DL-carnitine (0.01 to 1 mM) on whole cell voltage-activated calcium channel currents carried by calcium or barium and Ca(2+)-activated chloride currents were studied in cul...

Palmitoyl-L-carnitine modifies the function of vascular endothelium.

Cardiovasc. Res. 28 , 129-134, (1994)

Palmitoyl-L-carnitine, which accumulates in ischaemic myocardium, may influence the function of vascular endothelium in the ischaemic area. The aim of the study was therefore to examine the effect of ...