Polyoxyl 15 hydroxystearate

Names

[ Name ]:
Polyoxyl 15 hydroxystearate

[Synonym ]:
Polyethylene glycol (15)-hydroxystearate
Polyoxyethylated 12-hydroxystearic acid
Macrogol (15)-hydroxystearate

Biological Activity

[Description]:

Polyoxyl 15 hydroxystearate is a nonionic surfactant and emulsifier. Polyoxyl 15 hydroxystearate is used for improving the solubility and dissolution of poorly watersoluble drugs[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Polyoxyl 15 hydroxystearate is found to be effective in enhancing the solubility and stability of Curcumin (HY-N0005)[2]. Polyoxyl 15 hydroxystearate is employed as a carrier to build up a stable CoQ10-loaded micelle delivery system[3].

[References]

[1]. Cho HJ, et al. Poly(lactic-co-glycolic) Acid/Solutol HS15-Based Nanoparticles for Docetaxel Delivery. J Nanosci Nanotechnol. 2016;16(2):1433‐1436.

[2]. Seo SW, et al. Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol® HS15 as a carrier. Int J Pharm. 2012;424(1-2):18‐25.

[3]. Liu L, et al. Kolliphor® HS 15 Micelles for the Delivery of Coenzyme Q10: Preparation, Characterization, and Stability. AAPS PharmSciTech. 2016;17(3):757-766.

Chemical & Physical Properties

[ Density]:
1.048 g/cm3 at 20 °C

[ Melting Point ]:
25-30 °C

[ Molecular Formula ]:
C₄₇H₉₄O₁₉

[ Molecular Weight ]:
963.23800

[ Flash Point ]:
272 ℃

[ Exact Mass ]:
962.63900

[ PSA ]:
216.21000

[ LogP ]:
4.13460

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24-37

[ RIDADR ]:
NONH for all modes of transport

Articles

Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.

Sci. Rep. 5 , 17956, (2015)

Cyclooxygenase-2 (COX-2) is activated in response to ischemia and significantly contributes to the neuroinflammatory process. Accumulation of COX-2-derived prostaglandin E2 (PGE2) parallels the substa...

Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.

Cancer Res. 51 , 897-902, (1991)

A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance ...

Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results.

Int. J. Pharm. 365(1-2) , 143-149, (2009)

The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded mic...