Dihydroavermectin B1b

Names

[ Name ]:
Dihydroavermectin B1b

[Synonym ]:
ivermectin B1b
IVERMECTIN B1B (DIHYDROAVERMECTIN B1B, 22, 23-DIHYDROAVERMECTIN B1B )
DIHYDROAVERMECTIN B1B

Biological Activity

[Description]:

Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[In Vitro]

Ivermectin and Ivermectin B1b are the most potent inhibitors of contraction and motility in both susceptible isolates (H. contortus McMaster and and O. circumcincta McMaster) also show the highest resistance ratios in both species[3]. Vermectin is a macrocyclic lactone that acts as a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs) but has no modulatory activity on 5-HT3 receptors[4].

[In Vivo]

Ivermectin B1b causes snail death[1].

[References]

[1]. Katz N, et al. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. J Antibiot (Tokyo). 2017;70(5):680-684.

[2]. Bray M, et al. Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses. Antiviral Res. 2020;178:104805.

[3]. Demeler J, et al. Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. Parasitology. 2014;141(7):948-956.

[4]. Collins T, et al. Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol. 2010;78(2):198-204.