3-(Trifluoromethyl)benzyl chloride

Names

[ CAS No. ]:
705-29-3

[ Name ]:
3-(Trifluoromethyl)benzyl chloride

[Synonym ]:
m-(Trifluoromethyl)benzyl Chloride
EINECS 211-884-4
1-(Chloromethyl)-3-(trifluoromethyl)benzene
3-(Trifluoromethyl)benzyl chloride
Benzene, 1-(chloromethyl)-3-(trifluoromethyl)-
α'-Chloro-α,α,α-trifluoro-m-xylene
m-Xylene, α'-chloro-α,α,α-trifluoro-
MFCD00000908

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
179.1±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₆ClF₃

[ Molecular Weight ]:
194.581

[ Flash Point ]:
48.9±0.0 °C

[ Exact Mass ]:
194.011017

[ LogP ]:
3.06

[ Vapour Pressure ]:
1.3±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.457

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R10;R34

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 2920 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29036990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Distributed Drug Discovery, Part 3: using D(3) methodology to synthesize analogs of an anti-melanoma compound.

J. Comb. Chem. 11(1) , 34-43, (2009)

For the successful implementation of Distributed Drug Discovery (D(3)) (outlined in the accompanying Perspective), students, in the course of their educational laboratories, must be able to reproducib...

Distributed Drug Discovery, Part 2: global rehearsal of alkylating agents for the synthesis of resin-bound unnatural amino acids and virtual D(3) catalog construction.

J. Comb. Chem. 11 , 14-33, (2009)

Distributed Drug Discovery (D(3)) proposes solving large drug discovery problems by breaking them into smaller units for processing at multiple sites. A key component of the synthetic and computationa...

Synthesis and biological evaluation of a series of dithiocarbamates as new cholinesterase inhibitors.

Arch. Pharm. (Weinheim) 346(8) , 571-6, (2013)

In the present paper, a novel series of dithiocarbamates was synthesized via the treatment of 4-(trifluoromethyl)benzyl chloride with appropriate sodium salts of N,N-disubstituted dithiocarbamic acids...