5-HETE

Names

[ Name ]:
5-HETE

[Synonym ]:
5-hydroxy-6,8,11,14-eicosatetraenoicacid
5(S)-HETE
[S-(E,Z,Z,Z)]-5-Hydroxy-6,8,11,14-eicosatetraenoic Acid
5-Hpete
5-HETE
5-Hydroxyicosatetraenoic acid
(5S,6E,8Z,11Z,14Z)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid
(5S,6E,8Z,11Z,14Z)-5-Hydroxy-6,8,11,14-icosatetraenoic acid
5-hydroxyeicosatetraenoicacid
6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (5S,6E,8Z,11Z,14Z)-
(S)-5-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic Acid
(5S,6E,8Z,11Z,14Z)-5-Hydroxy-6,8,11,14-eicosatetraenoic acid
5-Hydroxyeicosatetraenoate

Biological Activity

[Description]:

5(S)-HETE is an endogenous metabolite present in Blood that can be used for the research of Rheumatoid Arthritis, Rhinitis and Asthma[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Chavis C, et al. A method for the measurement of plasma hydroxyeicosatetraenoic acid levels. Anal Biochem. 1999 Jun 15;271(1):105-8.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
487.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₂O₃

[ Molecular Weight ]:
320.466

[ Flash Point ]:
262.8±25.2 °C

[ Exact Mass ]:
320.235138

[ PSA ]:
57.53000

[ LogP ]:
5.56

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.514

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX3873000

CHEMICAL NAME :: 6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (S-(E,Z,Z,Z))-

CAS REGISTRY NUMBER :: 70608-72-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H32-O3

MOLECULAR WEIGHT :: 320.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 5 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 10,1029,1989

Safety Information

[ Hazard Codes ]:
F,Xi

[ Risk Phrases ]:
11-36/37/38

[ RIDADR ]:
UN 1170 3/PG 2