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TTK21

Names

[ CAS No. ]:
709676-56-2

[ Name ]:
TTK21

[Synonym ]:
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide

Biological Activity

[Description]:

TTK21 (CBP-p300 activator TTK21) is a small molecule activator of CBP/p300 histone acetyltransferase activity with a maximal effect at a concentration of 275 uM; induces acetylation of histones H3 and H4 in vitro but not H2B and H2A; promotes neurogenesis and extends memory duration in adult mice, promotes regeneration and sprouting of sensory and motor axons, as well as recovery of sensory and motor functions in both the mouse and rat model of spinal cord injury.

[References]

References 1. Chatterjee S, et al. J Neurosci. 2013 Jun 26;33(26):10698-712. 2. Hutson TH, et al. Sci Transl Med. 2019 Apr 10;11(487). pii: eaaw2064. View Related Products by Target Histone Acetyltransferase (HAT)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
369.8±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H15ClF3NO2

[ Molecular Weight ]:
357.755

[ Flash Point ]:
177.4±27.9 °C

[ Exact Mass ]:
357.074341

[ LogP ]:
5.70

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.553

Related Compounds