cytosine

Names

[ CAS No. ]:
71-30-7

[ Name ]:
cytosine

[Synonym ]:
MFCD00006034
Cytosin
EINECS 200-749-5
Cytosinimine
Cytosine
4-aminopyrimidin-2-one
Cyt
Lamivudine Impurity 5
6-Aminopyrimidin-2(1H)-one

Biological Activity

[Description]:

6-Aminopyrimidin-2(1H)-one is an organic compound that belongs to the class known as pyrimidones.

[Related Catalog]:

Natural Products >> Quinones

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
445.8ºC at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₄H₅N₃O

[ Molecular Weight ]:
111.102

[ Flash Point ]:
223.4ºC

[ Exact Mass ]:
111.043259

[ PSA ]:
71.77000

[ LogP ]:
-2.29

[ Index of Refraction ]:
1.689

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7350150

CHEMICAL NAME :: 2(1H)-Pyrimidinone, 4-amino-

CAS REGISTRY NUMBER :: 71-30-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H5-N3-O

MOLECULAR WEIGHT :: 111.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2222 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 207,504,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3859 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 312 (estimated) No. of Female Employees: 303 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
UW7350150

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933591000

[ Summary ]:
HS:2933591000 4-aminopyrimidin-2(1h)-one VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile.

J. Bacteriol. 197(5) , 819-32, (2015)

Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal infections with symptoms ranging from mild diarrhea to fulminant colitis. Cyclic diguanosine monophosphate (c-di-GM...

Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation.

Mol. Cell. Biol. 35(6) , 1026-42, (2015)

The Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-hydroxymethylcytosine and further oxidized products. Tet1 and Tet2 are highly expressed in mouse pluripotent cells and d...

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.

Cell Death Differ. 22 , 1970-84, (2015)

Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...